Weight of evidence (WoE) is a key approach in modern toxicology especially when employing New Approaches Methodologies (NAM).
Author archives: Candice Johnson
Instem at the annual Genetic Toxicology Association meeting (GTA)
Here is our summary of the annual Genetic Toxicology Association meeting (GTA) which was held in Newark, Delaware.
Assessing drug safety with in silico modeling and clinical data integration
How can we assess drug safety with in silico modeling and clinical data integration?
4th Annual Extractables & Leachables Online Summit
The 4th Annual Extractables & Leachables (E&L) Online Summit will take place on March 7th and 8th. This event is hosted by Uventia and brings together scientists and toxicologists to discuss recent advances in E&L assessments.
The Regulatory Science Accelerator
Over the last few months, Dr Kevin Cross and Dr Arianna Bassan participated in the Reagan-Udall and U.S. Food and Drug Administration (FDA) Regulatory Science Accelerator.
Recent publications available online
We previously conducted research on the application of in silico methods in the assessment of extractables and leachables (E&L) and are happy to say that the manuscripts which detail these assessments are now available online.
The application of in silico approaches to food chemical assessments
Hazard identification and characterization for food safety assessment (e.g., flavourings, food contact materials, food contaminants) takes advantage of the availability of relevant data in appropriate databases as well as the application of in silico toxicology methods including category formation (i.e., chemical grouping), read-across, expert rule-based systems (i.e., structural alerts), and statistical-based systems (i.e., Quantitative Structure-Activity …
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Important Aspects to Consider in the Application of in silico Tools for Regulatory Contexts
This year has been very exciting for the computational toxicology group at Instem. Together with our collaborators, customers, partners and colleagues we progressed our efforts to further regulatory acceptance and use of in silico approaches to support the 3Rs.
Our Computational Toxicology 2023 Year-end Review
This year has been very exciting for the computational toxicology group at Instem. Together with our collaborators, customers, partners and colleagues we progressed our efforts to further regulatory acceptance and use of in silico approaches to support the 3Rs.
Thoughts on the (Q)SAR Assessment Framework (QAF)
The (Q)SAR Assessment Framework (QAF) was recently published by Organization for Economic Co-operation and Development (OECD) and presents an approach that can be used by regulators to assess the validity of (Quantitative) Structure-Activity Relationship (QSAR) models and their individual predictions.