The (Q)SAR Assessment Framework (QAF) was recently published by Organization for Economic Co-operation and Development (OECD) and presents an approach that can be used by regulators to assess the validity of (Quantitative) Structure-Activity Relationship (QSAR) models and their individual predictions.
Tag archives: (Q)SAR
Our Update of the Occupational Toxicology Roundtable
Instem presented at the Occupational Toxicology Roundtable.
What is the difference between the Klimisch Score and the Reliability Score?
Klimisch Score and the Reliability Score
Assessing whether In Silico models are fit-for-purpose
In Silico methods are used to predict a toxicological outcome directly from the chemical structure. In general, the state-of-the-art is to use multiple methodologies in combination with an expert review of prediction results.1 These approaches are used either as a direct replacement for an in vitro or in vivo assay or a part of a …
Continue reading “Assessing whether In Silico models are fit-for-purpose”
In silico toxicology assessments throughout the product life cycle
In silico toxicology refers to computational methods that predicts toxicological endpoints or mechanisms. It offers a cost-effective, rapid, and animal-free approach to support toxicological hazard assessments. There are increasing numbers of applications where it has been shown that in silico toxicology can be very useful as well as standardized procedures for performing in silico assessments.1,2 However, …
Continue reading “In silico toxicology assessments throughout the product life cycle”
World Congress on Alternatives
The World Congress on Alternatives and Animal Use in the Life Sciences is where scientists from academia, industry, government, and the non-profit sector meet to advance the 3Rs—to reduce, refine, and replace the use of animals. This year the conference – WC12 – is being held at Niagara Falls in Canada.1 The conference is organized …
Update from QSAR 2023
We recently attended the 20th International Workshop on (Q)SAR in Environmental and Health Sciences (QSAR 2023) held in Copenhagen. It was a great meeting with many interesting topics, including read-across approaches, new methods, and applications of (Q)SARs. We were happy to provide a course on regulatory uses of in silico modelling, covering different applications across …
Read-across collaborative working group
Instem will be starting a read-across collaborative working group.
(Q)SAR and veterinary medicinal products
(Q) SAR and veterinary medical products
Assessing carcinogenicity risk of nitrosamines and supporting the ICH S1B guideline
At this year’s SOT in Nashville (March 19-23, 2023), Instem will be organizing two workshops related to cancer assessments.1 In the first workshop, to be held on Tuesday, March 21, 4:30 PM – 5:30 PM (CT) in Room 101B, we will discuss carcinogenicity assessments aligned with the ICH S1B guideline2, specifically focusing on the weight …