FDA Modernization Act 2.0

The U.S. Congress recently passed the FDA Modernization Act 2.01 which permits the use of alternatives to animal studies as part of the FDA’s regulatory approval process. The new legislation explicitly identifies in silico models as one of these alternatives. This legislation is an important step forward in the use of alternative methods and will …

The Use of Artificial Intelligence to Support Safety Predictions

Last year, we were happy to contribute to a new book describing the use of both supervised and unsupervised machine learning approaches to support the prediction of toxicity and is illustrated with case studies related to regulatory submissions. The book chapter emphasized the importance of high-quality databases, containing toxicology and chemistry information. Such comprehensive databases …

Computational toxicology 2022 year-end review

The computational toxicology group here at Instem has had another busy year that has resulted in six publications and book chapters1-6, completion of existing and initiation of new collaborative working groups, as well as significant updates to our computational toxicology solutions. We have been collaborating on a number of research topics related to the in …

November 2022 computational toxicology conferences

We have been busy preparing for a number of upcoming conferences in November1. At the 2nd International Akademie Fresenius Gene-Tox Conference (November 3, 2022), Kevin Cross will discuss “N-Nitrosamine Impurities in Drugs – Introducing the EMA-Mutamind Project”. As part of the Extractables & Leachables Europe 2022 Conference (November 7 – 8, 2022) Glenn Myatt will …

Acute Toxicity in silico Battery

We are happy to have completed, after many years of work, a full battery of in silico models to evaluate acute toxicity. These models predict acute lethality by three routes of exposure (oral, dermal, inhalation), as well as skin and eye irritation/corrosion, and skin sensitization. They aim to support a variety of applications, including health, …

New read-across tool

Over the last year we have been working hard developing a new easy-to-use read-across solution that can instantaneously access over 200,000 chemicals with over 600,000 toxicity studies. The platform is able to integrate this data with chemicals and studies added by the user to conduct a read-across evaluation. It has been designed to directly support …

ELSIE Webinar on a Framework for Sensitization Assessment for E&L and Practical Application

We are delighted to be participating in an upcoming webinar organized by the Extractables and Leachables Safety Information Exchange (ELSIE) Consortium on the topic of a framework for sensitization assessment for Extractables and Leachables (E&L) on 22 September 2022, 9:30 – 11:00 AM ET1. We will be describing the development of a representative database of …

Publication of the special issue of computational toxicology on the in silico toxicology protocol initiative

In 2016, we initiated a new project to develop a standardized procedure for in silico experts performing assessments, similar to in vitro or in vivo test guidelines. This would streamline the application of in silico methods, ensure best practices are adopted, and defend its use to colleagues, peers, and regulators. The general framework paper1 was …

The Leadscope bacterial mutagenicity expert alerts journey to universal regulatory acceptance

It has taken over 10 years, but now Leadscope’s expert rule-based methodology is used every day to support submissions to regulatory agencies around the world, including pharmaceutical impurity assessments aligned with the ICH M7 guideline1, assessment of extractable and leachables, along with other applications. The following blog reviews this journey. The first step in this …

New in silico paper on acute toxicity

We are pleased to announce the publication of a new paper “Principles and Procedures for Assessment of Acute Toxicity Incorporating In Silico Methods”.1 This paper presents the results from a significant cross-industry collaboration to support the application of in silico methods for (1) product research and development, (2) product approval and registration as well as …