Improving the prediction of bioactivation in relation to drug-drug interactions using proprietary data

The bioactivation of drugs may result in the generation of reactive metabolites that irreversibly inactivate cytochrome P450 (requiring synthesis of new enzyme for recovery of activity). This process is referred to as mechanism-based inhibition (MBI) or time-dependent inhibition and is often involved in damaging drug-drug interactions (DDIs). Within the FDA guidance “In Vitro Drug Interaction …

Computational toxicology at the SOT 2021 Meeting

We are happy to be presenting at this year’s virtual SOT meeting1 on a number of topics throughout the course of the event. On Monday 15th March at 3pm (EST), we are covering some new areas at the session “Hot Topics in Computational Toxicology: New Developments that Support Regulatory Submissions.” This includes a discussion on …