We recently attended the 20th International Workshop on (Q)SAR in Environmental and Health Sciences (QSAR 2023) held in Copenhagen. It was a great meeting with many interesting topics, including read-across approaches, new methods, and applications of (Q)SARs.
We were happy to provide a course on regulatory uses of in silico modelling, covering different applications across many industries along with case studies. The course focused on a number of current applications such as the ICH M7 pharmaceutical impurities guideline (including an N-nitrosamines read-across example), the recently revised ICH S1B(R1) (carcinogenicity weight of evidence) guideline, and how in silico toxicology protocols can support current and future applications.
We also presented in a read-across session on predicting N-nitrosamines carcinogenicity potency in support of regulating acceptable intake levels of drugs.
In addition, we participated in the session “Regulatory use of acute oral toxicity predictions” organized by ECHA where we presented “A cross-industry collaboration to assess if acute oral toxicity (Q)SAR models are fit-for-purpose for GHS classification and labelling”. Following the presentation there was a panel discussion discussing important topics related to the use and acceptance of acute (Q)SAR models.
Please get in touch if you would like to review any of the material we presented at the conference (Glenn Myatt; email@example.com).