Instem will again have a large presence at this year’s Society of Toxicology meeting in Nashville.1 As part of the scientific program, we will be co-authoring on nine posters covering the spectrum of scientific topics where we are undertaking research and development activities. This work supports many regulatory mandates and guidelines, including SEND, carcinogenicity risk assessment (as part of nitrosamine analysis and ICH S1B), target safety assessment, and occupational hazard and risk evaluation. The titles of these posters (along with abstract and poster numbers) are:
- Challenges in SEND Conversion of Embryo Fetal Development (EFD) Studies in Compliance with the SENDIG DART v1.1 and Practical Examples Addressing the CDISC SEND Conformance Rules v4.0 (3172/P287)
- Application of in Silico Methods for the Definition of Occupational Exposure Banding (3176/ P291)
- Mechanisms of Nitrosamine Mutagenicity and Their Relationship to Carcinogenicity (3233/ P350)
- Polo-Like Kinase 4 (PLK4) Safety Review: Distilling the Risks with a Rapid Augmented Intelligence Approach (3096/ P202)
- In Silico Approaches in Carcinogenicity Hazard Assessment: Case Study of Pregabalin, a Nongenotoxic Mouse Carcinogen (3058/ P163)
- EMA Mutamind: Data Gap Analysis of N-Nitrosamines for Structure-Activity Relationship (3692/ P177)
- Predicting the Acute Toxicity 6-Pack to Support Health, Safety, and Environmental Product Stewardship (3671/ P156)
- Risk (Re)Assessment of N-Methyl-N-Nitrosophenethylamine for Use in Computing Acceptable Intake Levels of N-Nitrosamine Drug Substance-Related Impurities (4477/ P351)
- A protocol to support weight-of-evidence assessments in the ICH S1B guideline (5152/P253)
If you are unable to attend the meeting, please get in touch (Glenn Myatt; glenn.myatt@instem.com) and we would be happy to share copies of the posters and review these projects in detail.
References