Information for Computational Toxicologists
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As you may be aware, the US Food and Drug Administration (FDA), the European Medicines Agencies (EMA), and Health Canada have recently released a major update on N-nitrosamine impurities in human medicinal products supporting the categorical prediction of N-nitrosamine potency. The new approach is referred to as the Carcinogenic Potency Categorization Approach (CPCA) and is…Read more
Klimisch Score and the Reliability ScoreRead more
In Silico methods are used to predict a toxicological outcome directly from the chemical structure. In general, the state-of-the-art is to use multiple methodologies in combination with an expert review of prediction results.1 These approaches are used either as a direct replacement for an in vitro or in vivo assay or a part of a…Read more