In Silico Insider

Information for Computational Toxicologists

Welcome to In Silico Insider, a bi-weekly info-Blog that you’ll surely want to bookmark.

We invite you to step inside our online community, where our subject matter experts will share important insights about key issues facing our industry. From regulatory updates to industry innovations and scientific best practice, we hope this becomes a regular destination for you.

Update on the Mutamind N-nitrosamine project

Earlier this year, it was announced that Instem was part of the Mutamind industry and academic consortium of 9 beneficiaries, funded by EMA and led by Fraunhofer Institute for Toxicology and Experimental Medicine (ITEM)1. Instem is collaborating on this 2-year research project to further investigate the mutagenicity of different classes of N-nitrosamines to distinguish highly …

New paper discussing the assessment of abuse liability using blood-brain barrier QSAR models

Last year, we discussed the development of a new solution to support the assessment of abuse liability.1 This included a large database of over 4,000 chemicals from numerous sources including the US Drug Enforcement Agency (DEA) scheduled drugs and structural alerts to profile potential abuse liability. This assessment has now been extended to include a …

November 2022 computational toxicology conferences

We have been busy preparing for a number of upcoming conferences in November1. At the 2nd International Akademie Fresenius Gene-Tox Conference (November 3, 2022), Kevin Cross will discuss “N-Nitrosamine Impurities in Drugs – Introducing the EMA-Mutamind Project”. As part of the Extractables & Leachables Europe 2022 Conference (November 7 – 8, 2022) Glenn Myatt will …